Unnoticed sex reversal in amphibians due to artificial estrogen from pills

Hormonally active substances may contribute to global amphibian decline. Some compounds, for example from pharmaceuticals, occur in biologically relevant concentrations in freshwater ecosystems, and thus can affect the hormonal system and the sexual development of animals. Researchers have compared the effects of the pill estrogen ethinylestradiol (EE2) in three amphibian species. The study shows that EE2 can lead to a complete feminization of genetic males. Without molecular establishment of the genetic sex, this has remained partly unnoticed.

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Longtime mystery Clarified: Transporter protein involved in renal reabsorption of cystine

Cystinuria occurs in one out of every 7,000 in the world, but its curative treatment has not been established. AGT1/SLC7A13, a protein, is an unknown factor that binds with the protein rBAT/SLC3A2, of which mutations may cause cystinuria leading to serious kidney failure, report researchers.

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New, cost-effective therapy on the horizon: Magnesium treatment for genetic coagulation disorder

An international team of scientists was able to demonstrate in mouse and patient studies, how magnesium affects the production of blood platelets and that the TRPM7 channel function plays a key role in this process.

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Small cell lung cancer: Newly discovered clues to cause of chemoresistance

Small cell lung cancer is not usually detected until it is at an advanced stage, when metastases have already formed. Chemotherapy is very effective initially but, within a year, cancer recurs and this time does not respond to a course of chemotherapy. The research group has now managed to identify the reason for this chemoresistance.

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Certain type of training can improve driving skills of older adults

Older drivers can see their driving abilities improve by participating in certain types of training that improves the brain’s processing speed and how the mind reacts when attention is divided, according to a new study. Although vision issues, physical limitations and other health problems are associated with driving limitations, declining cognitive performance may be the strongest indicator of declining driving skills

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Three glycosyltransferases identified as significant mutational targets in colon cancer

Scientists have successfully characterized the mutational landscapes of glycosylation-associated genes in colon cancer, identifying three glycosyltransferases as significant mutational targets in CRC.

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Potential pathway for emergence of zoonotic malaria identified

The parasite responsible for a form of malaria now spreading from macaques to humans in South Asia could evolve to infect humans more efficiently, a step towards enhanced transmission between humans, according to a new study.

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