Autism-epilepsy connection explored in four studies

Epilepsy affects nearly 30 percent of all people with autism spectrum disorder (ASD), a neurobehavioral condition marked by impaired social and language development. Conversely, many patients with epilepsy display ASD-like behavior. Recent studies suggest that epileptic seizures impair the neural pathways needed for socialization, but the details of this process remain unclear.

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Falsified medicines taint global supply

The threat of falsified medications, also referred to as counterfeit, fraudulent, and substandard, can be quite real, yet the full scope and prevalence of the problem is poorly understood, say researchers. Counterfeit medicines have traditionally been defined as those for which the identity or source is mislabeled in a way that makes them appear to be a genuine product when they are not, though definitions of the problem itself are the subject of international debate.

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New tactic targets brain tumors

Patients who are obese, diabetic or both have the highest incidence of brain tumors, and they offer a clue that insulin is a factor for some glioblastoma patients. But a new study suggests drugs tested on such tumors targeted the wrong molecules.

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New pathway reveals how immune system is regulated, gives hope for chronic diseases

An important new way in which our immune systems are regulated has been uncovered by researchers, giving hope that understanding it will help tackle the debilitating effects of type 1 diabetes, rheumatoid arthritis and other serious diseases.

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Pancreatic cancer loses viral defenses when talking with supporting cells

Researchers have unlocked a way to make pancreatic cancer cells more vulnerable to cancer-killing viruses, known as oncolytic viruses. The scientists have discovered how they can exploit the communication, or cross-talk, between pancreatic cancer and a specific cell type that supports the tumor. They found that this cross-talk weakens the ability of both cell types to fight off cancer-fighting viruses.

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Video games in care homes: connecting older adults, or exposing age-related vulnerability?

Introducing video games as a means of bringing older adults in long-term care together may not always be an easy task, according to new research. Offering stimulating and accessible leisure activities such as this can be difficult for care providers as the impact of age-related changes and impairments on residents grows, authors of a new study warn.

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Ways to avoid catching diseases from pets

Pets can pass diseases to humans, especially when a pet owner’s immune system is compromised. Here, veterinarians outline ways for families to avoid disease transmission by choosing the right type of pet–or making small changes in the ways they enjoy the pets they already have.

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Adjuvant Ipilimumab effects survival after high risk lymph node and melanoma resection

Adjuvant Ipilimumab significantly improves recurrence-free survival in patients with completely resected stage III melanoma at high risk of disease recurrence, research indicates, but that this treatment was also associated with a high rate of immune-related adverse events.

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Childhood syndrome combining lung disease, arthritis identified

Using the latest genome sequencing techniques, a research team has identified a new autoimmune syndrome characterized by a combination of severe lung disease and arthritis. The hereditary disorder, which appears in early childhood, had never been diagnosed as a single syndrome. The new research revealed that it is caused by mutations in a single gene that disrupt how proteins are shuttled around within cells. Patients with the newly discovered syndrome have a poor prognosis, and at present can only be treated with anti-inflammatory and immunosuppressant drugs. Many have lung disease so severe that they must receive lung transplants.

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