Thursday, March 31, 2016

Two-fold higher risk of concussions for NFL players during colder game-days, study finds

NFL players had a two-fold greater risk of concussions and 1.5 times higher risk for ankle injuries when games were played at colder temperatures, a new study has found.



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US autism rate unchanged in new CDC report

A new CDC report finds the prevalence of autism spectrum disorder largely unchanged from two years ago, at one in 68 children..



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Possibility of curbing synapse loss in Alzheimer's

Researchers show how brain connections, or synapses, are lost early in Alzheimer’s disease and demonstrate that the process starts – and could potentially be halted – before telltale plaques accumulate in the brain.



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Protease-activated receptors differentially regulate endothelial nitric oxide synthase

It has been established that the activation of protease-activated receptor-2 (PAR-2) phosphorylates endothelial nitric oxide synthase (eNOS)-Ser-1177 through a distinct signaling pathway that leads to the production of the potent vascular vasodilator nitric oxide (NO), while PAR-1 activation phosphorylates eNOS-Thr-495 and decreases NO production through a separate pathway. In this study, we have identified a variance in PAR coupling to the signaling pathways that regulate eNOS phosphorylation and NO production in adult human endothelial cells.



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Mom's smoking alters fetal DNA

A study of over 6,000 mothers and their newborn children – one of the largest studies of its kind – solidifies the evidence that smoking cigarettes while pregnant chemically modifies a fetus’ DNA, mirroring patterns seen in adult smokers. The researchers also identify new development-related genes affected by smoking. The work suggests a potential explanation for the link between smoking during pregnancy and health complications in children.



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Pharmacy on demand: Portable system can be configured to produce different drugs

Researchers have developed a compact, portable pharmaceutical manufacturing system that can be reconfigured to produce a variety of drugs on demand.



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Born to run? Study suggests love of exercise starts in the womb

Female mice that voluntarily exercise during pregnancy have offspring that are more physically active as adults.



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Scientists discover a missing link between tau and memory loss

Scientists have long known that the protein tau is involved in dementia, but until recently, they did not understand how it hindered cognitive function. In a new study, researchers reveal how tau disrupts a cell’s ability to strengthen connections with other cells, preventing memories from forming.



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3-D 'mini-retinas' grown from mouse and human stem cells

Stem cell science has progressed so that researchers can now share recipes for making human retinas – the part of the eye that is sensitive to light. Researchers now have another efficient way to make 3-D retina organoids, which mimic the organ’s tissue organization, from mouse or human stem cells. Their version of ‘mini-retinas’ offers new perspectives on retina growth, injury, and repair.



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Virus evolution differs by species of mosquito carrier

A new study on how the West Nile virus evolves in four species of mosquitos shows that viruses accumulate mutations in their insect carriers that reduce how well they reproduce when passed on to a bird host. Viruses carried by one of the tropical species were best able to maintain their reproductive fitness and thus spread. The study could help in the prediction of future viral outbreaks.



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