It has been established that the activation of protease-activated receptor-2 (PAR-2) phosphorylates endothelial nitric oxide synthase (eNOS)-Ser-1177 through a distinct signaling pathway that leads to the production of the potent vascular vasodilator nitric oxide (NO), while PAR-1 activation phosphorylates eNOS-Thr-495 and decreases NO production through a separate pathway. In this study, we have identified a variance in PAR coupling to the signaling pathways that regulate eNOS phosphorylation and NO production in adult human endothelial cells.
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